RFRP-1 (human)

Cat. No. 5677

RFRP-1 (human) Met-Pro-His-Ser-Phe-Ala-Asn-Leu-Pro-Leu-Arg-Phe-NH2

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Biological Activity

Potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats. GnIH homolog.

Technical Data

M.Wt:
1428.72
Formula:
C67H101N19O14S
Sequence:
MPHSFANLPLRF

(Phe-12 = C-terminal amide)

Storage:
Store at -20°C
CAS No:
311309-25-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Nichols et al (2010) Human RFamide-related peptide-1 diminishes cellular and integrated cardiac contractile performance. Peptides 31 2067. PMID: 20797420.

Gouardères et al (2006) Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of [35S]GTPγS binding. Neuropharmacology 52 376. PMID: 17011599.

Hinuma et al (2000) New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat.Cell.Biol. 2 703. PMID: 11025660.

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Keywords: RFRP-1 (human), supplier, neuropeptide, FF, receptors, NPFF1, NPFF2, GPR147, prolactin, RFamide-related, peptides, cardiac, myocytes, agonists, agonism, endogenous, Tocris Bioscience, Neuropeptide FF/AF Receptor Agonist products

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