AZ PFKFB3 26
Cat. No. 5675
Chemical Name: (2S)-N-[4-[[3-Cyano-1-(2-methylprop
Biological ActivityPotent and selective PFKFB3 inhibitor (IC50 = 0.023 μM). Selective for PFKFB3 over PFKFB2 and PFKFB1 isoforms (IC50 values are 0.382 μM and 2.06 μM, respectively). Reduces levels of fructose-1,6-bisphosphate in A549 cells (IC50 = 0.343 μM). Exhibits no significant inhibition of other kinases.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Boyd et al (2015) Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3. J.Med.Chem. 58 3611. PMID: 25849762.
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Keywords: AZ PFKFB3 26, supplier, AZPFKFB326, phosphofructokinase2, PFKFB3, inhibitors, inhibits, fructose-1,6-bisphosphate, kinase, cancer, Tocris Bioscience, PFKFB3 Inhibitor products
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