Cat. No. 5674
Chemical Name: 2-[2-Methyl-4-[[[4-methyl-2-[4-(tri
Biological ActivityPotent and selective PPARδ agonist (EC50 = 1.2 nM). Displays <1000-fold selectivity over other PPAR subtypes. Increases ABC A1 transporter expression and induces apolipoprotein A1-mediated cholesterol efflux in vitro. Also increase serum HDL cholesterol and lowers small, dense LDL levels in obesity in vivo models.
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Certificate of Analysis / Safety Data Sheet
Oliver et al (2001) A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc.Natl.Acad.Sci.USA. 98 5306. PMID: 11309497.
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Keywords: GW 501516, supplier, GW501516, Potent, selective, PPARδ, agonists, agonism, reverse, cholesterol, transporter, ATP-binding, cassette, A1, obesity, peroxisome, proliferator-activated, receptors, delta, Tocris Bioscience, PPARδ Agonist products