Cat. No. 5667
Chemical Name: B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5
Biological ActivitySIRT1 activator. Inhibits proliferation of breast cancer cell lines expressing mutant p53. Induces G2/M cell cycle arrest and apoptosis in triple negative breast cancer cells (TNBCs) in vitro.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Ponnusamy et al (2015) Activation of sirtuin-1 promotes renal fibroblast activation and aggravates renal fibrogenesis. J.Pharmacol.Exp.Ther 354 142. PMID: 26022003.
Yi et al (2013) Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells. Oncotarget 4 984. PMID: 23846322.
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Keywords: YK 3-237, supplier, YK3-237, SIRT1, sirtuins, activators, activates, deacetylases, antiproliferative, Tocris Bioscience, Sir 2-like Family Deacetylase Activator products