YK 3-237

Cat. No. 5667new

YK 3-237 C19H21BO7 [1215281-19-8]

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Chemical Name: B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid

Biological Activity

SIRT1 activator. Inhibits proliferation of breast cancer cell lines expressing mutant p53. Induces G2/M cell cycle arrest and apoptosis in triple negative breast cancer cells (TNBCs) in vitro.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Ponnusamy et al (2015) Activation of sirtuin-1 promotes renal fibroblast activation and aggravates renal fibrogenesis. J.Pharmacol.Exp.Ther 354 142. PMID: 26022003.

Yi et al (2013) Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells. Oncotarget 4 984. PMID: 23846322.

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Keywords: YK 3-237, supplier, YK3-237, SIRT1, sirtuins, activators, activates, deacetylases, antiproliferative, Tocris Bioscience, Sir 2-like Family Deacetylase Activator products

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