Cat. No. 5664
Chemical Name: Ethyl 2-[(4-chlorophenyl)amino]-4-thiazol
Biological ActivityOct3/4 inducer; promotes Oct3/4 expression and stabilizes the Oct3/4 protein in HEK293 cells. Induces expression of pluripotent-associated genes Lin28, Sox2 and Nanog, and suppresses Rex1. Induces 15-fold increase in Oct3/4 expression in human primary fibroblasts.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Cheng et al (2015) Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and derivatives are potent inducers of Oct3/4. J.Med.Chem. 58 5742. PMID: 26143659.
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Keywords: O4I2, supplier, octamer, binding, transcription, factors, oct4, inducing, compound, 2, Oct3/4, inducers, pluripotent, stem, cells, induction, Tocris Bioscience, Reprogramming products
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