Cat. No. 5660

NVP CXCR2 20 C15H11F2N3OS [1029521-30-9]

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Chemical Name: 4-Cyclopropyl-2-[[(2,3-difluorophenyl)methyl]thio]-1,6-dihydro-6-oxo5-pyrimidinecarbonitrile

Biological Activity

Potent and selective CXCR2 antagonist (IC50 = 40 nM). Exhibits selectivity for CXCR2 over a panel of 49 other GPCRs. Orally bioavailable.

Technical Data

Soluble to 50 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Porter et al (2014) The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists. Bioorg.Med.Chem.Lett. 24 3285. PMID: 24974342.

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Keywords: NVP CXCR2 20, supplier, NVPCXCR220, chemokine, cxc, receptors, antagonists, antagonism, orally, bioavailable, potent, selective, Tocris Bioscience, Chemokine CXC Receptor Antagonist products

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