Cat. No. 5655
Chemical Name: N-(2,3-Dihydro-1,4-benzodioxin-6-yl
Biological ActivityPotent HIF-1α inhibitor (IC50 = 14 nM). Inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. Cytotoxic to a range of cancer cell types in vitro.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Minegishi et al (2013) Discovery of indenopyrazoles as a new class of hypoxia inducible factor (HIF)-1 inhibitors. ACS Med.Chem.Lett. 4 297. PMID: 24900662.
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Keywords: GN 44028, supplier, GN44028, HIF-1a, HIF-1alpha, HIF-1α, inhibitors, hypoxia-inducible, factors, inhibits, cytotoxic, Tocris Bioscience, Hypoxia Inducible Factor Inhibitor products