Cat. No. 5655
Chemical Name: N-(2,3-Dihydro-1,4-benzodioxin-6-yl
Biological ActivityPotent HIF-1α inhibitor (IC50 = 14 nM). Inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. Cytotoxic to a range of cancer cell types in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Minegishi et al (2013) Discovery of indenopyrazoles as a new class of hypoxia inducible factor (HIF)-1 inhibitors. ACS Med.Chem.Lett. 4 297. PMID: 24900662.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses GN 44028 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: GN 44028, supplier, GN44028, HIF-1a, HIF-1alpha, HIF-1α, inhibitors, hypoxia-inducible, factors, inhibits, cytotoxic, Tocris Bioscience, Hypoxia Inducible Factor Inhibitor products
Find multiple products by catalog number
New Products in this Area
Gene switch ligand for use in induceable gene expression systemsML 334
Inhibitor of Keap1- Nrf2 interactionRA 839
Nrf2 activator; inhibits Nrf2/Keap1 interaction
October 30 - November 3, 2016
Boston, MA, USA