GN 44028

Cat. No. 5655new

GN 44028 C18N15N3O2 [1421448-26-1]

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Chemical Name: N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine

Biological Activity

Potent HIF-1α inhibitor (IC50 = 14 nM). Inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. Cytotoxic to a range of cancer cell types in vitro.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Minegishi et al (2013) Discovery of indenopyrazoles as a new class of hypoxia inducible factor (HIF)-1 inhibitors. ACS Med.Chem.Lett. 4 297. PMID: 24900662.

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Keywords: GN 44028, supplier, GN44028, HIF-1a, HIF-1alpha, HIF-1α, inhibitors, hypoxia-inducible, factors, inhibits, cytotoxic, Tocris Bioscience, Hypoxia Inducible Factor Inhibitor products

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