Cat. No. 5653
Chemical Name: 4-[4-(4-Methoxyphenyl)-5-[[[3-(4-me
Biological ActivityInhibitor of canonical Wnt signaling (IC50 = 790 nM). Targets the β-catenin destruction complex (GSK-3ß/AXIN/APC). Increases AXIN2 and decreases active β-catenin levels in colorectal cancer (CRC) cells. Also arrests cell cycle in G1 and inhibits proliferation of CRC cells in vitro. Inhibits tumor growth and formation in mouse models.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Waaler et al (2011) Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res. 71 197. PMID: 21199802.
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Keywords: JW 74, supplier, JW74, canonical, Wnt, signaling, pathway, inhibitors, inhibits, cancer, β-catenin, AXIN2, Tocris Bioscience, Other Wnt Signaling Inhibitor products
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