Cat. No. 5653
Chemical Name: 4-[4-(4-Methoxyphenyl)-5-[[[3-(4-me
Biological ActivityInhibitor of canonical Wnt signaling (IC50 = 790 nM). Targets the β-catenin destruction complex (GSK-3ß/AXIN/APC). Increases AXIN2 and decreases active β-catenin levels in colorectal cancer (CRC) cells. Also arrests cell cycle in G1 and inhibits proliferation of CRC cells in vitro. Inhibits tumor growth and formation in mouse models.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Waaler et al (2011) Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res. 71 197. PMID: 21199802.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses JW 74 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: JW 74, supplier, JW74, canonical, Wnt, signaling, pathway, inhibitors, inhibits, cancer, β-catenin, AXIN2, Tocris Bioscience, Other Wnt Signaling Inhibitor products
Find multiple products by catalog number
New Products in this Area
Wnt signaling inhibitor; binds the PDZ domain of the Dishevelled (Dvl) proteinAMBMP hydrochloride
Wnt canonical signaling activator; also tubulin polymerization inhibitor
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for ISSCR 2017.