Cat. No. 5653
Chemical Name: 4-[4-(4-Methoxyphenyl)-5-[[[3-(4-me
Biological ActivityInhibitor of canonical Wnt signaling (IC50 = 790 nM). Targets the β-catenin destruction complex (GSK-3ß/AXIN/APC). Increases AXIN2 and decreases active β-catenin levels in colorectal cancer (CRC) cells. Also arrests cell cycle in G1 and inhibits proliferation of CRC cells in vitro. Inhibits tumor growth and formation in mouse models.
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Certificate of Analysis / Safety Data Sheet
Waaler et al (2011) Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res. 71 197. PMID: 21199802.
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Keywords: JW 74, supplier, JW74, canonical, Wnt, signaling, pathway, inhibitors, inhibits, cancer, β-catenin, AXIN2, Tocris Bioscience, Other Wnt Signaling Inhibitor products