Hydroxychloroquine sulfate

Cat. No. 5648

Hydroxychloroquine sulfate C18H28ClN3O5S [747-36-4]

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Chemical Name: 2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol sulfate

Biological Activity

Autophagy inhibitor. Inhibits growth and induces apoptosis of renal cancer cells in vitro. Also inhibits TLR9.

Technical Data

M.Wt:
433.95
Formula:
C18H28ClN3O5S
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
747-36-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Lee et al (2015) Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells. PLoS ONE 10 e0131464. PMID: 26134285.

Lamphier et al (2014) Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol.Pharmacol. 85 429. PMID: 24342772.

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Keywords: Hydroxychloroquine sulfate, supplier, TLR9, toll-like, receptors, inhibitors, autophagy, inhibits, cancer, Tocris Bioscience, Autophagy Inhibitor products

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