Cat. No. 5647
Chemical Name: N-(2-Aminophenyl)-4-[(3,4-dihydro-4
Biological ActivityPotent and selective HDAC2/3 inhibitor (IC50 values are 16 and 30 nM, respectively). Exhibits >250-fold selectivity for HDAC2/3 over other HDAC isoforms. Promotes apoptosis of leukemia cell lines in vitro. Also attenuates IL-6 production in rheumatoid arthritis PBMCs in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Boissinot et al (2012) Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192. Leuk.Res. 36 1304. PMID: 22818799.
Gillespie et al (2012) Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthrit.Rheumat. 64 418. PMID: 21952924.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses MI 192 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: MI 192, supplier, MI192, potent, selective, HDAC2, HDAC3, histones, deacetylases, Tocris Bioscience, Histone Deacetylase Inhibitor products
Find multiple products by catalog number
New Products in this Area
HDAC5 and HDAC9 inhibitorMC 1742
Potent class I and IIb HDAC inhibitorYK 3-237
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.