MI 192

Cat. No. 5647

MI 192 C24H21N3O2 [1415340-63-4]

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Chemical Name: N-(2-Aminophenyl)-4-[(3,4-dihydro-4-methylene-1-oxo-2(1H)-isoquinolinyl)methyl]benzamide

Biological Activity

Potent and selective HDAC2/3 inhibitor (IC50 values are 16 and 30 nM, respectively). Exhibits >250-fold selectivity for HDAC2/3 over other HDAC isoforms. Promotes apoptosis of leukemia cell lines in vitro. Also attenuates IL-6 production in rheumatoid arthritis PBMCs in vitro.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Boissinot et al (2012) Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192. Leuk.Res. 36 1304. PMID: 22818799.

Gillespie et al (2012) Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthrit.Rheumat. 64 418. PMID: 21952924.

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Keywords: MI 192, supplier, MI192, potent, selective, HDAC2, HDAC3, histones, deacetylases, Tocris Bioscience, Histone Deacetylase Inhibitor products

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