EML 425

Cat. No. 5646

EML 425 C27H24N2O4 [1675821-32-5]

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Chemical Name: 5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione

Biological Activity

Reversible and non-competitive CBP/p300 inhibitor (IC50 values are 1.1 and 2.9 μM, respectively). Cell permeable.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Milite et al (2015) A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach. J.Med.Chem. 58 2779. PMID: 25730130.

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Keywords: EML 425, supplier, EML425, CBP, CREB, proteins, histone, lysine, acetyltransferases, inhibits, inhibitors, HAT, KAT, reversible, non-competitive, Tocris Bioscience, Histone Acetyltransferase Inhibitor products

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