MSC 2032964A

Cat. No. 5641

MSC 2032964A C16H13F3N6O [1124381-43-6]

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Chemical Name: N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide

Biological Activity

Potent and selective ASK1 inhibitor (IC50 = 93 nM). Selective for ASK1 over a panel of 210 kinases. Blocks LPS-induced ASK1 and p38 phosphorylation in cultured mouse astrocytes. Suppresses neuroinflammation in a mouse EAE model. Orally bioavailable and brain penetrant.

Technical Data

Soluble to 20 mM in DMSO and to 10 mM in ethanol with gentle warming
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Guo et al (2010) Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol.Med. 2 504. PMID: 21064192 .

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Keywords: MSC 2032964A, supplier, MSC2032964A, apoptosis, signal, regulating, kinase, 1, ASK1, inhibits, inhibitors, potent, selective, orally, bioavailable, neuroinflammation, EAE, experimental, autoimmune, encephalomyelitis, Tocris Bioscience, ASK1 Inhibitor products

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