Cat. No. 5641
Chemical Name: N-[5-(Cyclopropylamino)-7-(trifluor
Biological ActivityPotent and selective ASK1 inhibitor (IC50 = 93 nM). Selective for ASK1 over a panel of 210 kinases. Blocks LPS-induced ASK1 and p38 phosphorylation in cultured mouse astrocytes. Suppresses neuroinflammation in a mouse EAE model. Orally bioavailable and brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Guo et al (2010) Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol.Med. 2 504. PMID: 21064192 .
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Keywords: MSC 2032964A, supplier, MSC2032964A, apoptosis, signal, regulating, kinase, 1, ASK1, inhibits, inhibitors, potent, selective, orally, bioavailable, neuroinflammation, EAE, experimental, autoimmune, encephalomyelitis, Tocris Bioscience, ASK1 Inhibitor products
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