Cat. No. 5636
Chemical Name: 4-[4-[[5-(2-Fluorophenyl)-2-furanyl
Biological Activityβ-TrCP1 ligase inhibitor. Inhibits IκBα ubiquitination (IC50 = 5.2 μM) without affecting proteasome activity. Blocks LPS-induced expression of inflammatory cytokines in human myelomonocytic cells. Suppresses antigen-induced NFκB expression, inflammation and mucus production in airways of OVA-sensitized mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Hirose et al (2008) GS143, an IκB ubiquitination inhibitor, inhibits allergic airway inflammation in mice. Biochem.Biophys.Res.Comm. 374 507. PMID: 18656449.
Nakajima et al (2008) A novel small-molecule inhibitor of NF-κB signaling. Biochem.Biophys.Res.Comm. 368 1007. PMID: 18275844.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses GS 143 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: GS 143, supplier, GS143, E3, ubiquitin, ligase, ubiquitination, inhibits, inhibitors, NFkappaB, NFκB, NFKB, anti-inflammatory, inflammation, Beta-TrCP1, B-TrCP1, βTrCP1, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.