Cat. No. 5636
Chemical Name: 4-[4-[[5-(2-Fluorophenyl)-2-furanyl
Biological Activityβ-TrCP1 ligase inhibitor. Inhibits IκBα ubiquitination (IC50 = 5.2 μM) without affecting proteasome activity. Blocks LPS-induced expression of inflammatory cytokines in human myelomonocytic cells. Suppresses antigen-induced NFκB expression, inflammation and mucus production in airways of OVA-sensitized mice.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Hirose et al (2008) GS143, an IκB ubiquitination inhibitor, inhibits allergic airway inflammation in mice. Biochem.Biophys.Res.Comm. 374 507. PMID: 18656449.
Nakajima et al (2008) A novel small-molecule inhibitor of NF-κB signaling. Biochem.Biophys.Res.Comm. 368 1007. PMID: 18275844.
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Keywords: GS 143, supplier, GS143, E3, ubiquitin, ligase, ubiquitination, inhibits, inhibitors, NFkappaB, NFκB, NFKB, anti-inflammatory, inflammation, Beta-TrCP1, B-TrCP1, βTrCP1, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products