AZ Dyrk1B 33

Cat. No. 5632new

AZ Dyrk1B 33 C19H16N4 [1679330-37-0]

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Chemical Name: 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine

Biological Activity

Potent and selective ATP-competitive Dyrk1B kinase inhibitor (IC50 = 7 nM); displays distinct cellular effects when compared to DYRK1B knockdown through siRNA. Demonstrates cellular in vitro activity (IC50 = 194 nM). Exhibits better selectivity than AZ 191 (Cat. No 5232); displays no off-target effects against a panel of 124 kinases tested (no kinase was inhibited above 50% at 1 μM).

Technical Data

M.Wt:
300.36
Formula:
C19H16N4
Solubility:
Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1679330-37-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kettle et al (2015) Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J.Med.Chem. 58 2834. PMID: 25738750.

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Keywords: AZ Dyrk1B 33, supplier, AZDyrk1B33, Dyrk1B, kinase, inhibitors, inhibits, dual, specificity, tyrosine, phosphorylation, regulated, kinases, potent, Tocris Bioscience, DYRK Inhibitor products

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