Dolasetron mesylate

Cat. No. 5629

Dolasetron mesylate C19H20N2O3.CH3SO3H [115956-13-3]

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Chemical Name: 3-Oxooctahydro-2,6-methano-2H-quinolizin-8-yl 1H-indole-3-carboxylate methanesulfonate

Biological Activity

Potent and selective 5-HT3 receptor antagonist (pIC50 = 7.55). Exhibits 200-fold selectivity for 5-HT3 over 5-HT1A, 5-HT1B and 5-HT2 receptors, and a range of other GPCRs. Blocks the 5-HT-elicited von Bezold-Jarisch reflex in rats and suppresses cisplatin-induced vomiting in ferrets.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Miller (1993) Pharmacological properties of dolasetron, a potent and selective antagonist at 5-HT3 receptors. Drug Dev. Res. 28 87.

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Keywords: Dolasetron mesylate, supplier, 5-HT3, antagonists, GPCRs, vomiting, potent, selective, antagonism, antiemetic, serotonin, Tocris Bioscience, 5-HT3 Receptor Antagonist products

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5-HT Receptors Scientific Review

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