Cat. No. 5629
Chemical Name: 3-Oxooctahydro-2,6-methano-2H-quino
Biological ActivityPotent and selective 5-HT3 receptor antagonist (pIC50 = 7.55). Exhibits 200-fold selectivity for 5-HT3 over 5-HT1A, 5-HT1B and 5-HT2 receptors, and a range of other GPCRs. Blocks the 5-HT-elicited von Bezold-Jarisch reflex in rats and suppresses cisplatin-induced vomiting in ferrets.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Miller (1993) Pharmacological properties of dolasetron, a potent and selective antagonist at 5-HT3 receptors. Drug Dev. Res. 28 87.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Dolasetron mesylate from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Dolasetron mesylate, supplier, 5-HT3, antagonists, GPCRs, vomiting, potent, selective, antagonism, antiemetic, serotonin, Tocris Bioscience, 5-HT3 Receptor Antagonist products
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.