HFI 142

Cat. No. 5627

HFI 142 C17H16N2O4 [332164-34-8]

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Chemical Name: Ethyl 2-amino-7-hydroxy-4-(3-pyridinyl)-4H-1-benzopyran-3-carboxylate

Biological Activity

Insulin-regulated aminopeptidase (IRAP) inhibitor (Ki = 2.01 μM). Improves memory in control and memory-deficient mice models.

Technical Data

M.Wt:
312.32
Formula:
C17H16N2O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
332164-34-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Albiston et al (2010) Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase. Mol.Pharmacol. 78 600. PMID: 20628006.

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Keywords: HFI 142, supplier, HFI, 142, inhibitors, inhibits, insulin-regulated, aminopeptidases, IRAPs, memory, Tocris Bioscience, Aminopeptidase Inhibitor products

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