ML 334

Cat. No. 5625

ML 334 C26H26N2O5 [1432500-66-7]

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Alternative Name: LH601A

Chemical Name: (1S,2R)-2-[[(1S)-1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]cyclohexanecarboxylic acid

Biological Activity

Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 1 μM). Promotes Nrf2 nuclear translocation and induces antioxidant response element (ARE) activity in vitro. Cell permeable.

Technical Data

M.Wt:
446.5
Formula:
C26H26N2O5
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1432500-66-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Rosini et al (2014) Oxidative stress in Alzheimer's disease: are we connecting the dots? J.Med.Chem. 57 2821. PMID: 24131448.

Hu et al (2013) Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg.Med.Chem.Lett. 23 3039. PMID: 23562243.

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Keywords: ML 334, supplier, ML334, Keap1, Nrf2, interaction, inhibitors, inhibits, inhibts, cell, permeable, nuclear, factor, erythroid-derived, 2, like, 2, Kelch, like-ECH-associated, protein, 1, Tocris Bioscience, Nrf2 Activator products

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