Cat. No. 5625
Alternative Name: LH601A
Chemical Name: (1S,2R)-2-[[(1S)-1-[(1,3-Dihydro-1,
Biological ActivityNrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 1 μM). Promotes Nrf2 nuclear translocation and induces antioxidant response element (ARE) activity in vitro. Cell permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Rosini et al (2014) Oxidative stress in Alzheimer's disease: are we connecting the dots? J.Med.Chem. 57 2821. PMID: 24131448.
Hu et al (2013) Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg.Med.Chem.Lett. 23 3039. PMID: 23562243.
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Keywords: ML 334, supplier, ML334, Keap1, Nrf2, interaction, inhibitors, inhibits, inhibts, cell, permeable, nuclear, factor, erythroid-derived, 2, like, 2, Kelch, like-ECH-associated, protein, 1, Tocris Bioscience, Nrf2 Activator products
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