Cat. No. 5621
Chemical Name: 4-[[[(2R)-1-(Benzo[b]thien-3-ylcarb
Biological ActivityPotent FFA2 antagonist (IC50 = 9 nM). Exhibits selectivity for FFA2 over FFA3. Inhibits acetate-induced human neutrophil migration in plasma or buffer. Also inhibits FFA2-induced expression of CD11b activation-specific epitope (AE) in human whole blood. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Pizzonero et al (2014) Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic. J.Med.Chem. 57 10044. PMID: 25380412.
If you know of a relevant reference for GLPG 0974 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses GLPG 0974 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: GLPG 0974, supplier, GLPG0974, free, fatty, acid, receptors, FFA2, antagonists, antagonism, potent, Tocris Bioscience, Free Fatty Acid Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Irreversible P2Y12 antagonist; antiplatelet and orally activeBigLEN (rat)
Potent GPR171 agonistBigLEN (mouse)
P2Y1 allosteric antagonistAC 265347
CaSR biased allosteric modulator7α,25-Dihydroxycholesterol
Highly potent GPR183 (EBI2) agonistAR-C 69931 tetrasodium salt
Highly potent P2Y12 antagonistFTY 720
Potent S1P receptor agonist; also immunosuppressantCinacalcet hydrochloride
Calcium-sensing receptor (CaSR) allosteric agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailableAMG 837 hemicalcium salt
Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonistUMB 68
GHB receptor ligandAZD 1283
High affinity P2Y12 antagonistEx 26
Potent and selective S1P1 receptor antagonist
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.