Cat. No. 5621
Chemical Name: 4-[[[(2R)-1-(Benzo[b]thien-3-ylcarb
Biological ActivityPotent FFA2 antagonist (IC50 = 9 nM). Exhibits selectivity for FFA2 over FFA3. Inhibits acetate-induced human neutrophil migration in plasma or buffer. Also inhibits FFA2-induced expression of CD11b activation-specific epitope (AE) in human whole blood. Orally bioavailable.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Pizzonero et al (2014) Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic. J.Med.Chem. 57 10044. PMID: 25380412.
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Keywords: GLPG 0974, supplier, GLPG0974, free, fatty, acid, receptors, FFA2, antagonists, antagonism, potent, Tocris Bioscience, Free Fatty Acid Receptor Antagonist products
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