N-Acetylcysteine amide

Cat. No. 5619

N-Acetylcysteine amide C5H10N2O2S [38520-57-9]

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Chemical Name: (2R)-2-(Acetylamino)-3-mercaptopropanamide

Biological Activity

Glutathione (GSH) precursor and cell permeable antioxidant. Improves neuronal mitochondrial bioenergetics, reduces tissue damage and enhances functional recovery following spinal cord injury in rats. Also enhances behavioral recovery in rats following traumatic brain injury. Neuroprotective.

Technical Data

M.Wt:
162.21
Formula:
C5H10N2O2S
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
38520-57-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Pandya et al (2014) N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI. Exp.Neurol. 257 106. PMID: 24792639.

Patel et al (2014) N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma. Exp.Neurol. 257 95. PMID: 24805071.

If you know of a relevant reference for N-Acetylcysteine amide please let us know.

Citations are publications that use Tocris products. Selected citations for N-Acetylcysteine amide include:

Gutierrez et al (2014) The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity. J Biol Chem 289 33568. PMID: 25301941.

Do you know of a great paper that uses N-Acetylcysteine amide from Tocris? If so please let us know.

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Keywords: N-Acetylcysteine amide, supplier, cell, permeable, antioxidant, neuroprotective, glutathione, precursor, GSH, organoids, Tocris Bioscience, Antioxidant products

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