Cat. No. 5619
Chemical Name: (2R)-2-(Acetylamino)-3-mercaptoprop
Biological ActivityGlutathione (GSH) precursor and cell permeable antioxidant. Improves neuronal mitochondrial bioenergetics, reduces tissue damage and enhances functional recovery following spinal cord injury in rats. Also enhances behavioral recovery in rats following traumatic brain injury. Neuroprotective.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Pandya et al (2014) N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI. Exp.Neurol. 257 106. PMID: 24792639.
Patel et al (2014) N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma. Exp.Neurol. 257 95. PMID: 24805071.
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Citations are publications that use Tocris products. Selected citations for N-Acetylcysteine amide include:
Gutierrez et al (2014) The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity. J Biol Chem 289 33568. PMID: 25301941.
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Keywords: N-Acetylcysteine amide, supplier, cell, permeable, antioxidant, neuroprotective, glutathione, precursor, GSH, organoids, Tocris Bioscience, Antioxidant products
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