Cat. No. 5617
Chemical Name: 5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyr
Biological ActivityPotent and selective JAK2 inhibitor (IC50 < 3 nM). Exhibits >50-fold selectivity for JAK2 over JAK3. Exhibits antitumor effects and inhibits formation of lung metastases in a mouse renal cancer model. Also inhibits STAT3 signaling, tumor angiogenesis and myeloid cell migration in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ioannidis S et al (2011) Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway. J.Med.Chem. 54 262. PMID: 21138246.
Xin et al (2011) Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480. Cancer Res. 71 6601. PMID: 21920898.
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Keywords: AZD 1480, supplier, AZD1480, JAK2, inhibitors, cancer, anticancers, metastasis, angiogenesis, STAT3, signaling, potent, selective, inhibits, Tocris Bioscience, JAK Kinase Inhibitor products
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