BS 181 dihydrochloride
Cat. No. 5608
Chemical Name: N5-(6-Aminohexyl)-3-(1-methylethyl)
Biological ActivitySelective cdk7 inhibitor (IC50 = 21 nM). Displays >40-fold selectivity for cdk7 over others cdks. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Ali et al (2009) The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 69 6208. PMID: 19638587.
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Keywords: BS 181 dihydrochloride, supplier, cyclin-dependent, kinase, 7, cdk7, BS-181, inhibitors, cancer, apoptosis, activating, 1397219-81-6, inhibits, Tocris Bioscience, Cyclin-Dependent Protein Kinase Inhibitor products
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