BS 181 dihydrochloride

Cat. No. 5608

BS 181 dihydrochloride C22H32N6.2HCl

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Chemical Name: N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride

Biological Activity

Selective cdk7 inhibitor (IC50 = 21 nM). Displays >40-fold selectivity for cdk7 over others cdks. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.

Technical Data

M.Wt:
453.45
Formula:
C22H32N6.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ali et al (2009) The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 69 6208. PMID: 19638587.

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Citations are publications that use Tocris products.

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Keywords: BS 181 dihydrochloride, supplier, cyclin-dependent, kinase, 7, cdk7, BS-181, inhibitors, cancer, apoptosis, activating, 1397219-81-6, inhibits, Tocris Bioscience, Cyclin-Dependent Protein Kinase Inhibitor products

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