Cat. No. 5607

GNF 7 C28H24F3N7O2 [839706-07-9]

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Chemical Name: N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide

Biological Activity

Ras signaling inhibitor; inhibits Ack1 and germinal center kinase (GCK). Suppresses proliferation, and induces cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. Prolongs survival in a leukemia cell xenotransplantation model in mice.

Technical Data

Soluble to 50 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Nonami et al (2015) Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach. Blood 125 3133. PMID: 25833960.

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Keywords: GNF 7, supplier, GNF7, RAS, inhibitors, inhibits, Ack1, germinal, centre, kinases, GCK, leukemia, TNK2, Tocris Bioscience, G Protein (Small) Inhibitor products

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