Cat. No. 5606
Chemical Name: 2-[[4-(Cyclopropylcarbonyl)-1-piper
Biological ActivityHigh affinity protein disulfide isomerase (PDI) modulator (Kd = 62 nM). Forces PDI to adopt an oxidized conformation and suppresses its activity. Neuroprotective.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kaplan et al (2015) Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective. Proc.Natl.Acad.Sci.U.S.A. 112 E2245. PMID: 25848045.
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Keywords: LOC14, supplier, LOC14, High, affinity, protein, disulfide, isomerase, PDI, allosteric, modulator, Huntington, disease, Tocris Bioscience, Other Reductase Modulator products
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