LOC14

Cat. No. 5606

LOC14 C16H19N3O2S [877963-94-5]

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Chemical Name: 2-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-1,2-benzisothiazol-3(2H)-one

Biological Activity

High affinity protein disulfide isomerase (PDI) modulator (Kd = 62 nM). Forces PDI to adopt an oxidized conformation and suppresses its activty. Neuroprotective.

Technical Data

M.Wt:
317.41
Formula:
C16H19N3O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
877963-94-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Kaplan et al (2015) Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective. Proc.Natl.Acad.Sci.U.S.A. 112 E2245. PMID: 25848045.

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Keywords: LOC14, supplier, LOC14, High, affinity, protein, disulfide, isomerase, PDI, allosteric, modulator, Huntington, disease, Tocris Bioscience, Other Reductase Modulator products

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