CINPA 1

Cat. No. 5605

CINPA 1 C23H29N3O3 [102636-74-8]

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Chemical Name: Ethyl [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamate

Biological Activity

Potent CAR antagonist (IC50 = 70 nM). Exhibits >90-fold selectivity for CAR over pregnane X receptor (PXR). Also selective over a panel of other nuclear receptors including FXR, LXR, PPARγ and RXR.

Technical Data

M.Wt:
395.49
Formula:
C23H29N3O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
102636-74-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Cherian et al (2015) CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol.Pharmacol. 87 878. PMID: 25762023.

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Keywords: CINPA 1, supplier, CINPA1, CAR, constitutive, androstane, receptors, potent, antagonists, Tocris Bioscience, Constitutive Androstane Receptor Antagonist products

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