Cat. No. 5605
Chemical Name: Ethyl [5-[(diethylamino)acetyl]-10,11-dih
Biological ActivityPotent CAR antagonist (IC50 = 70 nM). Exhibits >90-fold selectivity for CAR over pregnane X receptor (PXR). Also selective over a panel of other nuclear receptors including FXR, LXR, PPARγ and RXR.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Cherian et al (2015) CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol.Pharmacol. 87 878. PMID: 25762023.
If you know of a relevant reference for CINPA 1 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses CINPA 1 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: CINPA 1, supplier, CINPA1, CAR, constitutive, androstane, receptors, potent, antagonists, Tocris Bioscience, Constitutive Androstane Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Synthetic progesterone analogC-DIM 12
Nurr1 activator; inhibits NF-κB-dependent gene expression(S)-Equol
Potent estrogen receptor β (ERβ) agonistAilanthone
Potent inhibitor of androgen receptor (AR)(±)-ML 209
RORγt inverse agonist; suppresses Th17 cell differentiationAGN 193109
High affinity pan-RAR antagonistSR 9243
Selective LXR inverse agonist
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.