MI 14

Cat. No. 5604

MI 14 C19H23ClN6O3S [1715934-43-2]

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Chemical Name: N-[2-[[6-Chloro-3-[3-[(dimethylamino)sulfonyl]phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamide

Biological Activity

Potent and selective PI 4-K IIIβ inhibitor (IC50 = 54 nM). Exhibits >1,800-fold selectivity for PI 4-K IIIβ over PI 4-K IIIα and PI 4-K IIα, respectively. Exhibits antiviral activity against single-stranded positive sense RNA viruses in HeLa cell-based assays.

Technical Data

Soluble to 20 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Mejdrová et al (2015) Highly selective phosphatidylinositol 4-kinase IIIβ inhibitors and structural insight into their mode of action. J.Med.Chem. 58 3767. PMID: 25897704.

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Keywords: MI 14, supplier, MI14, antivirals, phostphatidylinositol, 4, kinases, inhibitors, inhibits, IIIbeta, PI4-Kinase, RNA, viruses, potent, selective, Tocris Bioscience, Other Kinase Inhibitor products

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