Cat. No. 1568
Alternative Names: N-Arachidonyldopamine, AA-DA
Chemical Name: N-[2-(3,4-Dihydroxyphenyl)ethyl]-5Z
Biological ActivityPotent endogenous cannabinoid and vanilloid receptor agonist, with no action at dopamine receptors. Selective for CB1 over CB2 receptors (Ki values are 0.25 and 12 μM respectively), and potent agonist at TRPV1 (VR1) receptors (EC50 ~ 50 nM). Metabolically stable and competitively inhibits FAAH and anandamide transport. Has cannabinoid and vanilloid actions in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Huang et al (2002) An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc.Natl.Acad.Sci.U.S.A. 99 8400. PMID: 12060783.
Bisogno et al (2000) N-acyl-dopamines: novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo. Biochem.J. 351 817. PMID: 11042139.
De Petrocellis et al (2000) Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. FEBS Lett. 483 52. PMID: 11033355.
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Citations are publications that use Tocris products. Selected citations for NADA include:
Kaszás et al (2012) Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. PLoS One 340 152. PMID: 22005042.
Pitcher et al (2007) Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia. J Pharmacol Exp Ther 3 17. PMID: 17603899.
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Keywords: NADA, supplier, Endogenous, CB1, agonists, vanilloid, inhibitors, inhibits, FAAH, AMT, TRPV1, cannabinoids, Receptors, Vanillioids, VR1, Channels, Transient, Receptor, Potential, cb1r, Tocris Bioscience, CB1 Receptor Agonist products
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April 1 - 5, 2017
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