Cat. No. 5603
Chemical Name: (6R)-4-(4-Chlorophenyl)-2,3,9-trime
Biological ActivityInactive control for (+)-JQ1 (Cat. No. 4499). Exhibits no significant interaction with BRD1-4 or a panel of other bromodomains.
Licensing InformationThis compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the (+)-JQ1 probe summary on the SGC website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Filippakopoulos et al (2010) Selective inhibition of BET bromodomains. Nature 468 1067. PMID: 20871596.
If you know of a relevant reference for (-)-JQ1 please let us know.
Citations are publications that use Tocris products. Selected citations for (-)-JQ1 include:
Perry et al (2015) BET bromodomains regulate transforming growth factor-β-induced proliferation and cytokine release in asthmatic airway smooth muscle. Scientific Reports 290 9111. PMID: 25697361.
Do you know of a great paper that uses (-)-JQ1 from Tocris? If so please let us know.
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Keywords: (-)-JQ1, supplier, inactive, analogs, negative, controls, bromodomains, BRD1, BRD2, BRD3, BRD4, Tocris Bioscience, Bromodomain products
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Tocris has a collaboration with the Structural Genomics Consortium (SGC) to provide the latest high quality epigenetics probes.