Cat. No. 5602
Chemical Name: 3-[(2,5-Dimethylphenyl)amino]-1-phe
Biological ActivityCD40-TRAF6 interaction inhibitor. Suppresses CD40-induced IL-1β and IL-6 expression in macrophages in vitro. Improves insulin sensitivity, reduces adipose tissue inflammation, and ameliorates hepatosteatosis in diet-induced obese mice.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Chatzigeorgiou et al (2014) Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc.Natl.Acad.Sci.U.S.A. 111 2686. PMID: 24492375.
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Keywords: 6877002, supplier, cd40, traf6, tnfalpha, tnfa, tnfα, superfamily, cytokines, receptors, inhibitors, inhibits, inflammation, obesity, diabetes, insulin, Tocris Bioscience, Cytokine Receptor products
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