6877002

Cat. No. 5602

6877002 C17H17NO [433249-94-6]

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Chemical Name: 3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one

Biological Activity

CD40-TRAF6 interaction inhibitor. Suppresses CD40-induced IL-1β and IL-6 expression in macrophages in vitro. Improves insulin sensitivity, reduces adipose tissue inflammation, and ameliorates hepatosteatosis in diet-induced obese mice.

Technical Data

M.Wt:
251.32
Formula:
C17H17NO
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
433249-94-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Chatzigeorgiou et al (2014) Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc.Natl.Acad.Sci.U.S.A. 111 2686. PMID: 24492375.

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Keywords: 6877002, supplier, cd40, traf6, tnfalpha, tnfa, tnfα, superfamily, cytokines, receptors, inhibitors, inhibits, inflammation, obesity, diabetes, insulin, Tocris Bioscience, Cytokine Receptor products

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