Cat. No. 5601
Chemical Name: 5,6-Dimethyl-9-oxo-9H-xanthene-4-ac
Biological ActivitymSTING agonist; selective for mouse STING over human STING. Induces IFN-β and cytokine production from bone marrow-derived dendritic cells. Causes tumor regression following intratumoral administration in mouse tumor models. Induces an adaptive immune response to reduce systemic tumor growth and provides immunological memory against autologous tumor re-challenge. Also antiviral.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Corrales et al (2015) Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 11 1018. PMID: 25959818.
Shirey et al (2011) The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-β-mediated antiviral activity in vitro and in vivo. J.Leukoc.Biol. 89 351. PMID: 21084628.
Phillips (1999) Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 126.96.36.199) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development. Biochem.Pharmacol. 58 303. PMID: 10423172.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses DMXAA from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: DMXAA, supplier, mouse, STING, antitumor, adaptive, immunity, tumors, immunology, microenvironment, antiviral, Tocris Bioscience, STING-Dependent Signaling Agonist products
Find multiple products by catalog number
New Products in this Area
Activator of STING-dependent signaling3',3'-cGAMP sodium salt
STING agonist2',3'-cGAMP sodium salt
Endogenous high affinity STING agonistc-Di-AMP sodium salt
Endogenous STING and DDX41 agonist; activates STING-dependent signaling
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.