Cat. No. 5601
Chemical Name: 5,6-Dimethyl-9-oxo-9H-xanthene-4-ac
Biological ActivitymSTING agonist; selective for mouse STING over human STING. Induces IFN-β and cytokine production from bone marrow-derived dendritic cells. Causes tumor regression following intratumoral administration in mouse tumor models. Induces an adaptive immune response to reduce systemic tumor growth and provides immunological memory against autologous tumor re-challenge. Also antiviral.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Corrales et al (2015) Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 11 1018. PMID: 25959818.
Shirey et al (2011) The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-β-mediated antiviral activity in vitro and in vivo. J.Leukoc.Biol. 89 351. PMID: 21084628.
Phillips (1999) Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 126.96.36.199) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development. Biochem.Pharmacol. 58 303. PMID: 10423172.
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Keywords: DMXAA, supplier, mouse, STING, antitumor, adaptive, immunity, tumors, immunology, microenvironment, antiviral, Tocris Bioscience, STING-Dependent Signaling Agonist products