A66

Cat. No. 5595

A66 C17H23N5O2S2 [1166227-08-2]

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Chemical Name: (2S)-N1-[2-(1,1-Dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide

Biological Activity

Potent and selective PI 3-kinase p110α inhibitor (IC50 = 32 nM). Exhibits >100-fold selectivity for p110α over other PI 3-kinase isoforms. Inhibits Akt signaling and tumor growth in SK-OV-3 xenografts in mice.

Technical Data

M.Wt:
393.53
Formula:
C17H23N5O2S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1166227-08-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Jamieson et al (2011) A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem. J. 438 53. PMID: 21668414.

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Keywords: A66, supplier, PI, 3-kinase, PI3K, phosphoinositide, 3-kinase, inhibitors, potent, selective, inhibits, p110a, alpha, α, Tocris Bioscience, PI 3-kinase Inhibitor products

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