LCB 03-0110 dihydrochloride
Cat. No. 5592
Chemical Name: 3-[[2-[3-(4-Morpholinylmethyl)pheny
Biological ActivityPotent c-Src kinase inhibitor (IC50 = 1.3 nM). Also potent inhibitor of discoidin domain receptor 2 (DDR2) family tyrosine kinases, BTK and Syk. Suppresses LPS-induced activation of macrophages and TGF-β1- induced activation of fibroblasts in vitro. Also inhibits activation of macrophages and fibroblasts and suppresses scar formation in a wound healing model.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Sun et al (2012) LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation. J.Pharmacol.Exp.Ther. 340 510. PMID: 22128347.
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Keywords: LCB 03-0110 dihydrochloride, supplier, src, kinase, inhibitors, inhibits, potent, discoidin, domain, receptor, DDR, wound, healing, Bruton's, tyrosine, BTK, syk, anti-inflammatory, potent, Tocris Bioscience, Src Kinase Inhibitor products
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