WAY 181187 oxalate

Cat. No. 5589

WAY 181187 oxalate C15H13ClN4O2S2.C2H2O4

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Chemical Name: 1-[(6-Chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]-1H-indole-3-ethanamine oxalate

Biological Activity

High affinity and selective 5-HT6 agonist (Ki = 2.2 nM). Displays 60-fold selectivity over other 5-HT and monoamine receptors. Increases firing rate of 5-HT neurons. Modifies sleep and wakefulness profiles following direct injections into the dorsal raphe nucleus, in vivo. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Technical Data

M.Wt:
470.91
Formula:
C15H13ClN4O2S2.C2H2O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Brouard et al (2015) Pharmacological evidence for 5-HT6 receptor modulation of 5-HT neuron firing in Vivo. ACS Chem.Neurosci. 6 1241. PMID: 25837696.

Cole et al (2007) Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT6 receptor agonist. J.Med.Chem. 50 5535. PMID: 17948978.

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Keywords: WAY 181187 oxalate, supplier, WAY181187, oxalate, [554403-49-5], High, affinity, and, selective, 5-HT6, agonists, activates, sleep, serotonin, receptors, serotonergic, Tocris Bioscience, 5-HT6 Receptor Agonist products

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