Cat. No. 5588
Chemical Name: 4-Bromo-N'-butylbenzohydrazide
Biological ActivityClass I HDAC inhibitor (IC50 values are 0.06, 0.1, 0.5 and 1.5 μM for HDACs 3, 2, 1 and 8, respectively). Exhibits >6-fold selectivity over other HDACs. Induces accumulation of acetylated histones in HCT116 cells in vitro. Inhibits proliferation of a range of cancer cell lines. Arrests cells at G1/S transition.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Wang et al (2015) Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem.Biol. 22 273. PMID: 25699604.
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Keywords: UF 010, supplier, UF010, histone, deacetylase, inhibitors, inhibits, HDAC, classI, cancer, proliferation, cell, cycle, arrest, antiproliferative, epigenetics, Tocris Bioscience, Histone Deacetylase Inhibitor products
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