Yoda 1

Cat. No. 5586

Yoda 1 C13H8Cl2N4S2 [448947-81-7]

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Chemical Name: 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine

Biological Activity

Piezo1 channel activator. Slows the inactivation phase of transient currents, sensitizes Piezo1 to activation by pressure, and partially activates channels in the absence of external pressure, in HEK cells expressing Piezo1 channels.

Technical Data

M.Wt:
355.27
Formula:
C13H8Cl2N4S2
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
448947-81-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Syeda et al (2015) Chemical activation of the mechanotransduction channel Piezo1. ELife 4 e07369. PMID: 26001275.

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Keywords: Yoda 1, supplier, Yoda1, Piezo1, calcium, channels, activators, sensitizers, sensitizes, Ca2+, currents, mechanotransduction, Tocris Bioscience, Other Calcium Channel Activator products

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