Balicatib

Cat. No. 5585

Balicatib C23H33N5O2 [354813-19-7]

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Chemical Name: N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide

Biological Activity

Potent and selective cathepsin K inhibitor (IC50 values are 1.4, 56 and 480 nM for human, rat and mouse cathepsin K, respectively). Exhibits >300-fold selectivity for cathepsin K over cathepsins L, B and S. Long term supratherapeutic dosing increases tissue levels of cathepsins L and B in rats.

Technical Data

M.Wt:
411.54
Formula:
C23H33N5O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
354813-19-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Desmarais et al (2008) Effect of cathepsin k inhibitor basicity on in vivo off-target activities. Mol.Pharmacol. 73 147. PMID: 17940194.

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Keywords: Balicatib, supplier, cathepsins, K, inhibitors, potent, selective, inhibits, Tocris Bioscience, Cathepsin Inhibitor products

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