Cat. No. 5580
Chemical Name: 4-[6-[4-[2-(4-Morpholinyl)ethoxy]ph
Biological ActivityType I BMP receptor inhibitor (Ki values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro. Enhances liver regeneration in vivo.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Tsugawa et al (2014) Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration. J.Pharmacol.Exp.Ther. 351 549. PMID: 25271257.
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Keywords: DMH2, supplier, Type-1, BMP, bone, morphogenetic, protein, receptors, inhibitors, inhibits, ALK6, ALK2, ALK3, Tocris Bioscience, BMP and Other Activin Receptor Inhibitor products
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