Cat. No. 5580
Chemical Name: 4-[6-[4-[2-(4-Morpholinyl)ethoxy]ph
Biological ActivityType I BMP receptor inhibitor (Ki values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro. Enhances liver regeneration in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Tsugawa et al (2014) Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration. J.Pharmacol.Exp.Ther. 351 549. PMID: 25271257.
If you know of a relevant reference for DMH2 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses DMH2 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: DMH2, supplier, Type-1, BMP, bone, morphogenetic, protein, receptors, inhibitors, inhibits, ALK6, ALK2, ALK3, Tocris Bioscience, BMP and Other Activin Receptor Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and selective ALK2 inhibitorLDN 212854
Potent bone morphogenetic protein type I (ALK) inhibitorLDN 193189 dihydrochloride
Potent and selective ALK2 and ALK3 inhibitor; promotes neural induction of hPSCs
July 8 - 12, 2017