Cat. No. 5579
Chemical Name: 3-(9H-Pyrido[2,3-b]indol-4-ylamino)
Biological ActivityPotent and selective breast tumor kinase (Brk, also known as tyrosine-protein kinase 6, PTK6) inhibitor (IC50 = 3.15 nM). Exhibits >1000-fold selectivity for Brk over a panel of other kinases. Inhibits proliferation of breast cancer cells in vitro.
Licensing InformationSold under license from Martin-Luther-Universität-Halle-Wittenburg
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Mahmoud et al (2014) Discovery of 4-anilino α-carbolines as novel Brk inhibitors. Bioorg.Med.Chem.Lett. 24 1948. PMID: 24650640.
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Keywords: Tilfrinib, supplier, potent, selective, breast, tumor, kinases, Brk, antiproliferative, cancer, tyrosine-protein, kinases, 6, TK6, inhibitors, inhibits, Tocris Bioscience, Other Kinase Inhibitor products
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