Cat. No. 5577

S4 C15H17N3O4S [1330061-67-0]

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Chemical Name: 4-[[[(3,5-Dimethylphenyl)amino]carbonyl]amino]phenyl sulfamate

Biological Activity

High affinity and selective CA IX and CA XII inhibitor (Ki values are 2, 7, 547 and 5600 nM for CA XII, IX, II andI, respectively). Inhibits migration and proliferation of breast cancer cells in vitro. Inhibits lung metastasis in mice bearing breast tumor xenografts, without affecting primary tumor.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Gieling et al (2012) Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. J.Med.Chem. 55 5591. PMID: 22621623.

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Keywords: S4, supplier, carbonic, anhydrase, IX, XII, high, affinity, selective, inhibitors, inhibits, metastasis, migration, cancer, antimetastatic, Tocris Bioscience, Carbonic Anhydrase Inhibitor products

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