Cat. No. 5575
Chemical Name: 11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt
Biological ActivityJNK inhibitor (Kd values are 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Inhibits LPS-induced proinflammatory cytokine and nitric oxide production in vitro. Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo. Anti-inflammatory and immunosuppressive. Also releases NO upon metabolism by liver microsomes.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Atochin et al (2016) A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice. Neurosci.Lett. 618 45. PMID: 26923672.
Schepetkin et al (2015) Anti-Inflammatory effects and joint protection in collagen-induced arthritis after treatment with IQ-1S, a selective c-Jun N-terminal kinase Inhibitor. J.Pharmacol.Exp.Ther. 353 505. PMID: 25784649.
Schepetkin et al (2012) Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol.Pharmacol. 81 832. PMID: 22434859.
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Keywords: IQ 1S, supplier, IQ1S, JNK, inhibitors, inhibits, anti-inflammatory, immunosuppresents, NO, donor, Tocris Bioscience, JNK/c-Jun Inhibitor products
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