Lei-Dab 7

Cat. No. 5571

Lei-Dab 7 Ala-Phe-Cys-Asn-Leu-Arg-Dab-Cys-Gln-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Ile-Gly-Asp-Lys-Cys-Glu-Cys-Val-Lys-His-NH2

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Biological Activity

High affinity, selective KCa2.2 (SK2) channel blocker (Kd = 3.8 nM). Exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, IK, Kv and Kir2.1. Increases theta-burst responses and increases LTP in rat hippocampal slices in vitro. Convulsive in vivo.

Technical Data

M.Wt:
3392.06
Formula:
C141H236N46O39S6
Sequence:
AFCNLRXCQLSCRSLGLLGKCIGDKCECVKH

(Modifications: X = Dab, Disulfide bridges: 3-21, 8-26, 12-28, His-31 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
1061556-49-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kasumu et al (2012) Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem.Biol. 19 1340. PMID: 23102227.

Kramar et al (2004) A novel mechanism for the facilitation of theta-induced long-term potentiation by brain-derived neurotrophic factor. J.Neurosci. 24 5151. PMID: 15175384.

Shakkottai et al (2001) Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J.Biol.Chem. 276 43145. PMID: 11527975.

If you know of a relevant reference for Lei-Dab 7 please let us know.

Citations are publications that use Tocris products. Selected citations for Lei-Dab 7 include:

Sargin et al (2016) Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels Elife 5 e21416. PMID: 27874831.

Do you know of a great paper that uses Lei-Dab 7 from Tocris? If so please let us know.

Keywords: Lei-Dab 7, supplier, Lei-Dab7, selective, potent, small, conductance, calcium, activated, potassium, channels, K+, Ca2+, inhibitors, inhibits, KCa2.2, SK2, blockers, Tocris Bioscience, Calcium-Activated Potassium (KCa) Channel Blocker products

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