Cat. No. 5570
Chemical Name: 7-Ethoxy-N3-(2-furanylmethyl)-3,9-a
Biological ActivityLysine deficient protein kinase (WNK) signaling inhibitor (IC50 = 16 μM). Inhibits binding of WNK1 and WNK4 to SPAK and phosphorylation of downstream transporters, NKCC1 and NCC, in mouse vascular smooth muscle and distal convoluted tubule cell cultures exposed to hypotonic shock, respectively.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Mori et al (2013) Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy. Biochem.J. 455 339. PMID: 23981180.
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Keywords: STOCK2S 26016, supplier, with, no, lysine, deficient, protein, kinase, WNK1, WNK4, SPAK, signaling, inhibitors, inhibits, antihypertensive, Tocris Bioscience, Other Kinase Inhibitor products
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