Cat. No. 5568
Alternative Name: terutroban
Chemical Name: (6R)-6-[[(4-Chlorophenyl)sulfonyl]a
Biological ActivityPotent thromboxane A2 (TP) inhibitor (IC50 = 16.4 nM). Inhibits U 46619 (Cat. No. 1932) induced human platelet aggregation and contraction of isolated rabbit saphenous vein in vitro. Also inhibits U 46619 induced increase in tracheal pressure in guinea pigs. Orally available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Wang et al (2014) Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists. ACS Med.Chem.Lett. 5 1015. PMID: 25221659.
Cimetière et al (1998) Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists. Bioorg.Med.Chem.Lett. 8 1375. PMID: 9871769.
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Keywords: S 18886, supplier, S18886, terutroban, thromboxane, A2, antagonist, platelet, aggregation, orally, availalble, prostanoids, inhibitors, inhibits, Tocris Bioscience, Prostanoid Receptor Antagonist products
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