S 18886

Cat. No. 5568

S 18886 C20H22ClNO4S [165538-40-9]

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Alternative Name: terutroban

Chemical Name: (6R)-6-[[(4-Chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid

Biological Activity

Potent thromboxane A2 (TP) inhibitor (IC50 = 16.4 nM). Inhibits U 46619 (Cat. No. 1932) induced human platelet aggregation and contraction of isolated rabbit saphenous vein in vitro. Also inhibits U 46619 induced increase in tracheal pressure in guinea pigs. Orally available.

Technical Data

M.Wt:
407.91
Formula:
C20H22ClNO4S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol with gentle warming
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
165538-40-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Wang et al (2014) Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists. ACS Med.Chem.Lett. 5 1015. PMID: 25221659.

Cimetière et al (1998) Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists. Bioorg.Med.Chem.Lett. 8 1375. PMID: 9871769.

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Keywords: S 18886, supplier, S18886, terutroban, thromboxane, A2, antagonist, platelet, aggregation, orally, availalble, prostanoids, inhibitors, inhibits, Tocris Bioscience, Prostanoid Receptor Antagonist products

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