Tiplaxtinin

Cat. No. 5565

Tiplaxtinin C24H16F3NO4 [393105-53-8]

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Alternative Names: PAI 039, tiplasinin

Chemical Name: α-Oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid

Biological Activity

Plasminogen activator inhibitor-1 (PAI-1) inhibitor (IC50 = 2.7 μM). Induces vascular smooth muscle cell apoptosis in vitro and reduces carotid artery neointimal formation in a rat vascular injury model. Promotes thrombolysis in rat and dog models of acute arterial thrombosis. Orally available.

Technical Data

M.Wt:
439.38
Formula:
C24H16F3NO4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
393105-53-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Simone et al (2015) A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage. Cell.Signal. 27 923. PMID: 25617690.

Elokdah et al (2004) Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization. J.Med.Chem. 47 3491. PMID: 15214776.

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Keywords: Tiplaxtinin, supplier, thrombolysis, thrombolytic, PAI-1, plasminogen, activator, inhibitors, inhibits, apoptosis, inducers, induces, orally, available, PAI039, Tocris Bioscience, Other Protease Inhibitor products

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