VTP 27999 trifluoroacetate

Cat. No. 5563

VTP 27999 trifluoroacetate C26H41ClN4O5.CF3CO2H [1013937-63-7]

Price and Availability

For VTP 27999 trifluoroacetate pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: Methyl N-[2-[(R)-(3-Chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]carbamate trifluoroacetate

Biological Activity

Highly potent and selective renin inhibitor (IC50 = 0.47 nM). Displays >1000-fold selectivity over related and unrelated off-targets. Blocks renin-stimulated ERK1/2 phosphorylation in vascular smooth muscle cells. Exhibits a different mode of action to aliskiren (Cat. No. 5491).

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>97 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Lu et al (2014) Renin inhibitor VTP-27999 differs from aliskiren: focus on their intracellular accumulation and the (pro)renin receptor. J.Hypertens. 32 1255. PMID: 24637873.

Jia et al (2011) Discovery of VTP-27999, an alkyl amine renin inhibitor with potential for clinical utility. ACS Med.Chem.Lett. 2 747. PMID: 24900262.

If you know of a relevant reference for VTP 27999 trifluoroacetate please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses VTP 27999 trifluoroacetate from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: VTP 27999 trifluoroacetate, supplier, VTP, 27999, trifluoroacetate, highly, potent, selective, renin, inhibitors, inhibits, Tocris Bioscience, Other Protease Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Fall/Winter 2016)

Our New Product guide highlights over 100 new products added in the second half of 2016. Request copy or view PDF today.

divider line

New Products in this Area


Selective high affinity MMP2 inhibitor

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.