Mps BAY 2a
Cat. No. 5562
Chemical Name: N-Cyclopropyl-4-[8-[(2-methylpropyl
Biological ActivityPotent and selective Mps1 inhibitor (IC50 = 1 nM for human enzyme). Selective for Mps1 over a panel of 220 kinases. Differentially inhibits human colon carcinoma cell proliferation. Blocks cell cycle progression by preventing spindle assembly checkpoint activation. Induces apoptosis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Jemaà et al (2013) Characterization of novel MPS1 inhibitors with preclinical anticancer activity. Cell Death Differ. 20 1532. PMID: 23933817.
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