Mps BAY 2a

Cat. No. 5562

Mps BAY 2a C29H28N6O [1382477-96-4]

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Chemical Name: N-Cyclopropyl-4-[8-[(2-methylpropyl)amino]-6-(5-quinolinyl)imidazo[1,2-a]pyrazin-3-yl]benzamide

Biological Activity

Potent and selective Mps1 inhibitor (IC50 = 1 nM for human enzyme). Selective for Mps1 over a panel of 220 kinases. Differentially inhibits human colon carcinoma cell proliferation. Blocks cell cycle progression by preventing spindle assembly checkpoint activation. Induces apoptosis.

Technical Data

M.Wt:
476.57
Formula:
C29H28N6O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1382477-96-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Jemaà et al (2013) Characterization of novel MPS1 inhibitors with preclinical anticancer activity. Cell Death Differ. 20 1532. PMID: 23933817.

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Keywords: Mps BAY 2a, supplier, MpsBAY2a, monopolar, spindle, 1, kinase, Mps1, inhibitors, inhibits, cancer, proliferation, cell, cycle, assembly, checkpoint, apoptosis, inducers, Tocris Bioscience, Monopolar Spindle 1 Kinase Inhibitor products

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