IHR-Cy3

Cat. No. 5561

IHR-Cy3 C58H63Cl3N6O10S2

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Chemical Name: (2-[3-[1-(6-[[7-[[4-Chloro-3-[[4-(2,5-dichlorobenzamido)phenyl]carbamoyl]phenyl]amino]-7-oxoheptylamino]-6-oxohexyl]-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1-propen-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-3H-indolium, inner salt

Biological Activity

Potent fluorescent Smo antagonist (IC50 = 100 nM). Non-fluorescent analog IHR 1 also available.

Technical Data

M.Wt:
1174.64
Formula:
C58H63Cl3N6O10S2
Solubility:
Soluble to 5 mM in DMSO
Purity:
>95 %
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 21 1680. PMID: 25484239.

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Citations are publications that use Tocris products.

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Keywords: IHR-Cy3, supplier, Potent, fluorescent, Smo, antagonists, antagonism, hedgehog, signalling, signaling, inhibitors, inhibits, response, smoothened, receptors, IHR1, Tocris Bioscience, Fluorescent Probe products

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