SSR 180711 hydrochloride
Cat. No. 5559
Chemical Name: 4-Bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-car
Biological ActivityPartial agonist at α7 nAChR. Enhances episodic memory and reverses MK-801-induced deficits in retention of episodic memory. Increases extracellular dopamine levels in rat prefrontal cortex. Also exhibits antidepressant-like properties.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Jones et al (2014) Effect of α7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats. Psychopharmacology (Berl). 231 673. PMID: 24057763.
Pichat et al (2007) SSR180711, a novel selective α7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia. Neuropsychopharmacology 32 17. PMID: 16936709.
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