SSR 180711 hydrochloride

Cat. No. 5559

SSR 180711 hydrochloride C14H17BrN2O2.HCl [446031-79-4]

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Chemical Name: 4-Bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate hydrochloride

Biological Activity

Partial agonist at α7 nAChR. Enhances episodic memory and reverses MK-801-induced deficits in retention of episodic memory. Increases extracellular dopamine levels in rat prefrontal cortex. Also exhibits antidepressant-like properties.

Technical Data

M.Wt:
361.66
Formula:
C14H17BrN2O2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
446031-79-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Jones et al (2014) Effect of α7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats. Psychopharmacology (Berl). 231 673. PMID: 24057763.

Pichat et al (2007) SSR180711, a novel selective α7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia. Neuropsychopharmacology 32 17. PMID: 16936709.

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Keywords: SSR 180711 hydrochloride, supplier, SSR180711, hydrochloride, partial, agonists, a7, nAChR, nicotine, acetylcholine, receptor, schizophrenia, episodic, memory, antidepressant, Tocris Bioscience, Nicotinic (α7) Receptor Agonist products

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