Cat. No. 5557

Dianicline C13H16N2O.2HCl [292634-27-6]

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Chemical Name: (5aS,8S,10aR)-5a,6,9,10-Tetrahydro-7H,11H-8,10a-methanopyrido[2',3':5,6]pyrano[2,3-d]azepine

Biological Activity

Selective α4β2 nAChR partial agonist (IC50 = 105 nM). Exhibits >20-fold selectivity for α4β2 over other nAChR subtypes. Increases dopamine turnover in rat nucleus accumbens in vivo. Orally bioavailable.

Technical Data

Soluble to 100 mM in water and to 20 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Rollema et al (2010) Pre-clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence. Br.J.Pharmacol. 160 334. PMID: 20331614 .

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Keywords: Dianicline, supplier, nicotinic, acetylcholine, receptors, nAChR, partial, agonists, agonism, selective, α, β, alpha4beta2, orally, bioavailable, Tocris Bioscience, Nicotinic (α4β2) Receptor Agonist products

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