JIP-1 (153-163)

Cat. No. 1565

JIP-1 (153-163) Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH2

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Alternative Name: TI-JIP

Biological Activity

Peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK.

Technical Data

M.Wt:
1341.6
Formula:
C61H104N20O14
Sequence:
RPKRPTTLNLF

(Modifications: Phe-11 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
438567-88-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Barr et al (2002) Identification of the critical features of a small peptide inhibitor of JNK activity. J.Biol.Chem. 277 10987. PMID: 11790767.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for JIP-1 (153-163) include:

Kumar et al (2015) The Ser/Thr kinase MAP4K4 drives c-Met-induced motility and invasiveness in a cell-based model of SHH medulloblastoma. Springerplus 4 19. PMID: 25625039.

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Keywords: JIP-1 (153-163), supplier, JNK-selective, inhibitors, inhibits, peptide, c-Jun, N-Terminal, Kinase, SAPKs, Stress-Activated, Protein, MAPK, Mitogen-Activated, protein, TIJIP, Tocris Bioscience, JNK/c-Jun Inhibitor products

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