Cat. No. 1565
Alternative Name: TI-JIP
Biological ActivityPeptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK.
(Modifications: Phe-11 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Barr et al (2002) Identification of the critical features of a small peptide inhibitor of JNK activity. J.Biol.Chem. 277 10987. PMID: 11790767.
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Citations are publications that use Tocris products. Selected citations for JIP-1 (153-163) include:
Kumar et al (2015) The Ser/Thr kinase MAP4K4 drives c-Met-induced motility and invasiveness in a cell-based model of SHH medulloblastoma. Springerplus 4 19. PMID: 25625039.
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Keywords: JIP-1 (153-163), supplier, JNK-selective, inhibitors, inhibits, peptide, c-Jun, N-Terminal, Kinase, SAPKs, Stress-Activated, Protein, MAPK, Mitogen-Activated, protein, TIJIP, Tocris Bioscience, JNK/c-Jun Inhibitor products
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