Cat. No. 5554

IHR 1 C20H12Cl4N2O2 [548779-60-8]

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Chemical Name: N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide]

Biological Activity

Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.

Technical Data

Soluble to 20 mM in DMSO with gentle warming
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 21 1680. PMID: 25484239.

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Keywords: IHR 1, supplier, IHR1, potent, smoothened, smo, antagonists, hedgehog, signaling, Tocris Bioscience, Smoothened Receptor Antagonist products

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