IHR 1

Cat. No. 5554

IHR 1 C20H12Cl4N2O2 [548779-60-8]

Price and Availability

For IHR 1 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide]

Biological Activity

Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro. Fluorescent analog IHR-Cy3 also available.

Technical Data

M.Wt:
454.13
Formula:
C20H12Cl4N2O2
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
548779-60-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 21 1680. PMID: 25484239.

If you know of a relevant reference for IHR 1 please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses IHR 1 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: IHR 1, supplier, IHR1, potent, smoothened, smo, antagonists, hedgehog, signaling, inhibitors, inhibits, response, smoothened, receptors, Tocris Bioscience, Smoothened Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

New Products in this Area

Prasugrel

Irreversible P2Y12 antagonist; antiplatelet and orally active

BigLEN (rat)

Potent GPR171 agonist

BigLEN (mouse)

GPR171 agonist

BPTU

P2Y1 allosteric antagonist

AC 265347

CaSR biased allosteric modulator

7α,25-Dihydroxycholesterol

Highly potent GPR183 (EBI2) agonist

AR-C 69931 tetrasodium salt

Highly potent P2Y12 antagonist

FTY 720

Potent S1P receptor agonist; also immunosuppressant

Cinacalcet hydrochloride

Calcium-sensing receptor (CaSR) allosteric agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable

AMG 837 hemicalcium salt

Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist

UMB 68

GHB receptor ligand

AZD 1283

High affinity P2Y12 antagonist

Ex 26

Potent and selective S1P1 receptor antagonist

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.