IHR 1

Cat. No. 5554

IHR 1 C20H12Cl4N2O2 [548779-60-8]

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Chemical Name: N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide]

Biological Activity

Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro. Fluorescent analog IHR-Cy3 also available.

Technical Data

M.Wt:
454.13
Formula:
C20H12Cl4N2O2
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
548779-60-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 21 1680. PMID: 25484239.

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Keywords: IHR 1, supplier, IHR1, potent, smoothened, smo, antagonists, hedgehog, signaling, inhibitors, inhibits, response, smoothened, receptors, Tocris Bioscience, Smoothened Receptor Antagonist products

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