Cat. No. 5554
Chemical Name: N,N'-1,4-Phenylenebis[2,5-dichlorobe
Biological ActivityPotent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro. Fluorescent analog IHR-Cy3 also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 21 1680. PMID: 25484239.
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Keywords: IHR 1, supplier, IHR1, potent, smoothened, smo, antagonists, hedgehog, signaling, inhibitors, inhibits, response, smoothened, receptors, Tocris Bioscience, Smoothened Receptor Antagonist products
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